Last Wednesday, October 7, 2015, Penn’s Center for Neurodegenerative Disease Research (CNDR) hosted their 15th Annual Marian S. Ware Research Retreat. This year, the theme was “Focusing on Parkinson’s Disease (PD) Alpha-synuclein at the University of Pennsylvania,” which included lectures from thirteen different University of Pennsylvania researchers (listed below) from the Perelman School of Medicine, School of Arts and Sciences, the School of Veterinary Medicine, and the Children’s Hospital of Philadelphia (CHOP) who are working on this protein and its role in PD.
With over 150 guests and 26 posters, the day-long event was yet another success. The posters covered topics not only related to alpha-synuclein and PD, but a variety of other ongoing clinical and basic research studies on PD and other neurodegenerative diseases such as Alzheimer’s disease and amyotrophic lateral sclerosis (ALS). As usual, prizes were awarded to the top three posters.
1st Place Poster Winner
Title: Dopamine induces toxic oligomers of a-synuclein leading to neurodegeneration and motor impairment in vivo
Authors: Danielle Mor1,2 (pictured center, with CNDR Director, Virginia M.-Y. Lee, PhD [left] and Director of CNDR Drug Discovery, Kurt Brunden, PhD[right]); Elpida Tsika3; Joseph R. Mazzulli4; Jennifer Grossman5; John H. Wolfe2,6,7; Harry Ischiropoulos1,2,7
Affiliations: 1 Department of Neuroscience, School of Medicine, University of Pennsylvania; 2 Children’s Hospital of Philadelphia Research Institute; 3 Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Switzerland; 4 Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL; 5 Stern College for Women, Yeshiva University, New York, NY; 6 Department of Pathobiology, School of Veterinary Medicine; 7 Department of Pediatrics, School of Medicine, University of Pennsylvania
2nd Place Poster Winner
Title: The Super Elongation Complex (SEC) modulates TDP-43 and G4C2 hexanucleotide repeat toxicity in amyotrophic lateral sclerosis disease models
Authors: Chia-Yu Chung (pictured), Nancy Bonini
Affiliation: Department of Biology, University of Pennsylvania
3rd Place Poster Winner
Title: Can drug-induced Parkinsonism reveal pre-motor Parkinson disease?
Authors: James F. Morley (pictured), Gang Cheng, Jacob G. Dubroff, Jayne R. Wilkinson, John E. Duda
Affiliations: PADRECC and Nuclear Medicine, PVAMC. Departments of Neurology and Radiology PSOM
For more information on Penn’s Center for Neurodegenerative Disease Research, visit: www.med.upenn.edu/cndr