Congratulations! Penn Medicine Neuropathologist Eddie Lee, MD, PhD Awarded $486,000 Doris Duke Grant to Support His Research in FTD and ALS.

EddieLeeLarge

Congratulations to Eddie Lee, MD, PhD, an assistant professor of Pathology and Laboratory Medicine in the Perelman School of Medicine at the University of Pennsylvania on receiving a three-year Clinical Scientist Development Award (CSDA) for $486,000 from the Doris Duke Charitable Foundation!

This grant will support his ongoing research in Frontotemporal Degeneration (FTD) and Amyotrophic Lateral Sclerosis (ALS).

 

“Being awarded the DDCF CDSA is a great honor, and an amazing validation of the translational approach that we take here at Penn to tackling neurodegenerative diseases.”

As head of the Translational Neuropathology Research Laboratory, Lee and his colleagues’ goal is to better understand the causes of these neurodegenerative diseases to be able to develop specific disease-modifying therapies.

With this grant, Lee plans to study a mutation in the gene C9orf72, the most common genetic cause of FTD and ALS, explained below.

“A subset of patients with the C9orf72 mutation exhibit DNA hypermethylation which partially silences the mutant C9orf72 gene.  We have found that this DNA hypermethylation is associated with reduced neuropathologic inclusions in brain tissue, raising the possibility that C9orf72 hypermethylation protects against disease.  We are pursuing this by studying the cohort of individuals with the C9orf72 mutation followed by Penn physicians in the PENN FTD Center and the ALS Center at Pennsylvania Hospital.  The hope is that understanding these molecular changes in patients and human tissues will lead to novel biomarkers of disease and potentially lead to personalized therapies.”

To learn more about the Doris Duke Charitable Foundation Clinical Scientist Development Award, visit: www.ddcf.org.

Full Penn Medicine News Release.

* Quotes courtesy of Eddie Lee, MD, PhD Assistant Professor of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania

 

 

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s