Hormonal Changes and Frailty in Older Adults

The work of Anne R. Cappola, MD, ScM, Associate Professor of Medicine in the Division of Endocrinology, Diabetes, and Metabolism and Director, Center for Clinical and Translational Research at the University of Pennsylvania, focuses mainly on hormonal changes and frailty in older adults. More specifically, her research looks at thyroid disease and what levels are actually “normal” for older adults and how these levels change as we age, as well as frailty and how the impact of exercise, especially resistance training, can help improve the mobility of frail older adults.

Most recently, Dr. Cappola was named one of the recipients of this year’s Outstanding Statistical Application Award from the American Statistical Association. The goal of the paper leading to this award for Dr. Cappola and her colleagues — including fellow Penn Medicine researcher and award recipient, Wensheng Guo, PhD — was to demonstrate their model for complex hormonal data which monitors multiple hormones and their relationship to one another at the same time in order to observe their patterns. Recognizing these patterns in older adults is important because it is not always the level of their hormones that changes, but it is the way that their bodies are able to adapt to the patterns that changes, and through this model, Dr. Cappola and her team are able to pick up on these relationships.

Learn more about Dr. Cappola’s research in the video below:



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