On Wednesday, June 8, 2016, the Institute on Aging hosted its annual Sylvan M. Cohen Retreat and Poster Session. This year’s retreat, titled “To sleep, per chance to age… and avoid Alzheimer’s disease,” was co-sponsored by Penn’s Center for Sleep and Circadian Neurobiology and explored the effects of sleep loss and it’s possible link to Alzheimer’s and other neurodegenerative conditions.
As usual, the event began with lunch and a series of lectures, but this year we had the pleasure of having J. Larry Jameson, MD, PhD, dean of the Perelman School of Medicine (PSOM), join us for opening remarks.
He expressed his excitement to see such collaboration amongst the two sponsoring centers and encouraged more of this, not only in the PSOM, but also across the University as a whole. “One of the secrets at Penn Medicine is that we have these catalytic centers and institutes and it’s even more impressive that there is often cross fertilization between them,” explained Dean Jameson.
Keynote speaker, David M. Holtzman, MD, professor and chairman, Department of Neurology at Washington University School of Medicine, kicked off the lectures by discussing his research in “Understanding the Relationships between Sleep, Protein Aggregation, and Alzheimer’s disease.”
Other topics, covered by our Penn Presenters, included (click for video interviews):
- “Using Drosophila to study the function of sleep throughout lifespan”
Matthew S. Kayser, MD, PhD, Assistant Professor of Psychiatry
- “Age-related changes in sleep-insights from the worm”
David M. Raizen, MD, PhD, Associate Professor of Neurology
- “Sleep loss leads to Protein Misfolding”
Nirinjini Naidoo, PhD, Research Associate Professor of Medicine
- “Chronic sleep loss: lasting effects on locus coeruleus neurons”
Sigrid C. Veasey, MD, Professor of Medicine
Immediately following the lectures, researchers from the University of Pennsylvania and beyond presented their current aging-related work at our annual Poster Session. Categories included basic science, clinical research, & education and community and awards were given to the top posters.
Enhancing a WNT-telomere feedback loop restores intestinal stem cell function in a human organotypic model of dyskeratosis congenita
Presenter: Dong-Hun Woo
Authors: Dong-Hun Woo, Qijun Chen, Ting-Lin B. Yang, M. Rebecca Glineburg, Carla Hoge, Nicolae A. Leu, F. Brad Johnson, and Christopher J. Lengner
AB Plaques Mediate Neuritic Plaque-like Tau Pathology that is Distinct from Perikaryal Tau Inclusions
Presenters: Zhuohao He
Authors: Zhuohao He, Jing L. Guo, Jennifer D. McBride, Lakshmi Changolkar, Bin Zhang, Ronald J. Gathagan, Hyesung Kim, Sneha Narasimhan, Kurt R. Brunden, John Q. Trojanowski, Virginia M.-Y. Lee
CLINICAL RESEARCH and EDUCATION & COMMUNITY *
Tau Pathology Influences Dementia Onset and Survival in Lewy Body Spectrum Disorders
Presenter: David Irwin
Authors: David J. Irwin, MD MSTR, Murray Grossman MD, Daniel Weintraub MD, Howard I. Hurtig MD, John E. Duda MD, Sharon X. Xie PhD, Edward B. Lee MD PhD, Vivianna M. Van Deerlin MD, PhD,Oscar L. Lopez MD, Julia K. Kofler MD, Peter T. Nelson, MD PhD, Randy Woltjer MD PhD, Joseph F. Quinn MD, Jeffery Kaye MD, James B Leverenz MD, Debby Tsuang MD, MSc, Katelan Longfellow MD, Dora Yearout BS, Walter Kukull PhD, C. Dirk Keene MD, PhD, Thomas J. Montine MD, PhD, Cyrus P. Zabetian MD MS, John Q. Trojanowski MD PhD
Clinical Profile of Older Adults with Mild or No Cognitive Impairment Who Receive Prescriptions for Cholinesterase Inhibitors and/or Memantine: A descriptive study from the PACE/PACENET BHL Caregiver Resources, Education and Support (CREST) Program
Presenter: Romika Dhar, MD
Authors: Romika Dhar, MD; Amy Benson, MSEd; Joel E. Streim, MD; David W. Oslin, MD
* Due to the number of posters submitted, the categories for Clinical Research and Education & Community were combined.
To view some of the full lectures from our retreat, click here.
* Please note: Some of the lectures are not available to view due to unpublished data being presented *
View more photos from our 2016 Sylvan M. Cohen Retreat Facebook album here.