Cerebrovascular Disease and Alzheimer’s: A lecture by IOA Visiting Scholar, Richard Mayeux, MD, MSc

Screen Shot 2017-12-13 at 1.55.13 PMOn Thursday, November 30, 2017, the University of Pennsylvania’s Institute on Aging (IOA) hosted their last Visiting Scholars Series lecture for the 2017 season featuring Richard Mayeux, MD, MSc. Dr. Mayeux is currently the Gertrude H. Sergievsky Professor of Neurology, Psychiatry and Epidemiology in the Gertrude H. Sergievsky Center and Taub Institute for Research on Alzheimer’s Disease and the Aging Brain. In addition, he is also the Chair of the Department of Neurology at Columbia University, New York.

Dr. Mayeux’s talk highlighted his research on cerebrovascular disease and its link to late-onset Alzheimer’s disease (LOAD). As described in a 2016 JAMA Neurology publication, Dr. Mayeux and his colleagues conducted a study of 6,553 participants — 4,044 women and 2,509 men with a mean age of 77 years. Upon using generalized mixed logistic regression models to test the association of cardiovascular disease (CV) risk factors with late-onset Alzheimer’s, they found that “in familial and sporadic LOAD, a history of stroke was significantly associated with increased disease risk and mediated the association between selected CV risk factors and LOAD, which appears to be independent of the LOAD-related genetic background.”

Essentially, the findings support the idea that 1) cerebrovascular disease is prevalent in the aged, and 2) cerebrovascular disease may trigger Alzheimer’s disease in a genetically susceptible person. Currently, Dr. Mayeux is working on a new grant to further investigate his idea and to look into how to handle the fact that cerebrovascular disease contributes to the phenotype of Alzheimer’s disease.

To read Dr. Mayeux’s full 2016 publication, “Contributions of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer’s Coordinating Center,” click here.


The 2017 Joseph A. Pignolo Award in Aging Research: Nathan Basisty, PhD

On Wednesday, November 29, 2017, the Institute on Aging hosted their annual Joseph A. Pignolo Award in Aging Research. This year’s speaker, Nathan Basisty, PhD, a postdoctoral research fellow at The Buck Institute for Research on Aging, received the award for his 2016 paper titled “Mitochondrial-targeted catalase is good for the old mouse proteome, but not for the young: ‘reverse’ antagonistic pleiotropy?” published in Aging Cell.

Dr. Basisty’s research focuses heavily on the role of protein homeostasis in aging. Protein homeostasis is the process by which a cell retains an equilibrium of proteins to maintain its proper functions. According to a 2013 publication in Nature, it is believed that “a cell’s failure to maintain proper protein homeostasis has a major role in ageing and age-related diseases” (Nature Reviews Molecular Cell Biology 14, 55-61 (2013) BH Toyama and MW Hetzer). Dr. Basisty and his team are also looking at the role of this process in longevity with several interventions intended to extend lifespan in mammals.

In terms of future research, Dr. Basisty plans on expanding his studies to focus on method development to improve how well proteins can be characterized in the cell as well as how we can characterize the way proteins are regulated — or “turnover” — in the cell.

Learn more in Dr. Basisty’s short video interview below:

Learn more about the Jospeh A. Pignolo Award in Aging Research here.