Cerebrovascular Disease and Alzheimer’s: A lecture by IOA Visiting Scholar, Richard Mayeux, MD, MSc

Screen Shot 2017-12-13 at 1.55.13 PMOn Thursday, November 30, 2017, the University of Pennsylvania’s Institute on Aging (IOA) hosted their last Visiting Scholars Series lecture for the 2017 season featuring Richard Mayeux, MD, MSc. Dr. Mayeux is currently the Gertrude H. Sergievsky Professor of Neurology, Psychiatry and Epidemiology in the Gertrude H. Sergievsky Center and Taub Institute for Research on Alzheimer’s Disease and the Aging Brain. In addition, he is also the Chair of the Department of Neurology at Columbia University, New York.

Dr. Mayeux’s talk highlighted his research on cerebrovascular disease and its link to late-onset Alzheimer’s disease (LOAD). As described in a 2016 JAMA Neurology publication, Dr. Mayeux and his colleagues conducted a study of 6,553 participants — 4,044 women and 2,509 men with a mean age of 77 years. Upon using generalized mixed logistic regression models to test the association of cardiovascular disease (CV) risk factors with late-onset Alzheimer’s, they found that “in familial and sporadic LOAD, a history of stroke was significantly associated with increased disease risk and mediated the association between selected CV risk factors and LOAD, which appears to be independent of the LOAD-related genetic background.”

Essentially, the findings support the idea that 1) cerebrovascular disease is prevalent in the aged, and 2) cerebrovascular disease may trigger Alzheimer’s disease in a genetically susceptible person. Currently, Dr. Mayeux is working on a new grant to further investigate his idea and to look into how to handle the fact that cerebrovascular disease contributes to the phenotype of Alzheimer’s disease.

To read Dr. Mayeux’s full 2016 publication, “Contributions of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer’s Coordinating Center,” click here.


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