REACT! Study, Round 2, comes to a close

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The University of Pennsylvania’s Institute on Aging wrapped up their second round of the Rhythm Experience and Africana Culture Trial (REACT!) on Monday, October 9, 2017.

The trial concluded with a celebratory award ceremony which included readings, art presentations, and a dance performance by the study participants. Dara Meekins, REACT! Study Coordinator, kicked off the ceremony with a welcome speech describing the importance and impact of this clinical trial. “This study was developed to investigate a culturally important form of physical activity that could enhance the neurocognitive health and physical and emotional well-being of older African Americans,” explained Dara. “Prior studies have shown promising effects of physical activity, but REACT! specifically seeks to provide a fun, engaging, and broadly translatable platform for reducing the health disparities that currently exist for older African Americans.”

Not all clinical trials are as pleasant and many require a variety of unfavorable medical procedures or testing. “I think this study shows you that if you don’t want to be probed or prodded with needles, we can still use your help,” says Dara.

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Lewis Reddick, REACT! education group participant, is a perfect example of the many ways this study is bettering the lives of older African Americans. “This program has let me know about things that I still can do that I thought I couldn’t, such as my reading and writing,” he explained. “I couldn’t write the way I used to, I couldn’t read the way I used to… and [this study] got me started again and it has inspired me to maybe even go back to school!”

Mr. Reddick also expressed his praise and appreciation for Dara and the rest of the REACT! team, including Samuel Gorka, study coordinator, as well as several student interns. “Everyone was kind and we had a great time!” he said. “I looked forward to everyday that I came!”

Below are some highlights from the REACT! Dance Group’s wonderful performance led by African Dance Instructor, Yattah Jones! Their performance is set to the sounds of African Conga drums and tells a story of celebration, life, vitality, harvest & rebirth through a fusion of Afro-Caribbean dance styles.

REACT! is an Alzheimer’s Association-funded research study being conducted at the University of Pennsylvania and the University of Pittsburgh (Pittsburgh).

Learn more about the REACT! Study here.

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Penn Medicine’s 6th Annual 5K for the IOA & Memory Mile Walk

It was a warm Fall morning on Sunday, September 24, 2017 as 371 runners and walkers and 70 volunteers gathered for Penn Medicine’s 6th Annual 5K for the IOA and Memory Mile Walk.

The fundraiser, which takes place throughout Penn Park and the University of Pennsylvania campus, raised a total of $49,260 this year for Alzheimer’s and aging-related disease research efforts at Penn’s Institute on Aging.

In addition to its usual run and walk, the event also included pre and post-race yoga sessions, entertainment provided by DeeJay007, and photobooth fun for the whole family. This year’s overall male winner, Alexis Tingan (pictured below, left), finished the race in 17 minutes and 35 seconds, with the overall female winner, Sara McCuaig (pictured below, right), not far behind him with a time of 19 minutes and 24 seconds.

To view the full list of race results, click here.

Last week, CBS Philly interviewed PJ Brennan, MD, Chief Medical Officer at Penn Medicine who created the event in memory of his father who lost his battle with Alzheimer’s disease. “I thought it would be a fun way to get my community here together and bring some attention to the work that the Institute on Aging does and raise some money for this novel research,” said Brennan during the interview.

To view more photos of the event, click here.

Advancing the Health of an Aging Population: Friends of the NIA (FoNIA) Briefing 2017

Screen Shot 2017-07-12 at 12.31.50 PMOn Friday, July 7, 2017, Friends of the National Institute on Aging (FoNIA) hosted its annual briefing on ‘Advancing the Health of an Aging Population.’ These briefings provide important updates on the groundbreaking research that is supported by the NIA to promote the health and well-being of older adults. While registration for this meeting is open to the public, it is most heavily attended by representatives of other aging-related organizations, advocacy groups, and staff of Senators and House Representatives.

In addition to a lecture by NIA Director, Richard J. Hodes, MD, and Deputy Director, Marie A. Bernard, MD, this year also featured a presentation by Penn Medicine’s David J. Irwin, MD, MSTR, assistant professor of Neurology at the University of Pennsylvania and clinical neurologist at the Penn FTD Center. Dr. Irwin’s presentation titled “Bringing the microscope to clinic: improving the diagnosis of Alzheimer’s disease and related disorders” discussed some of the current challenges of diagnosing Alzheimer’s and other neurodegenerative conditions and how researchers at Penn and beyond are working to overcome these challenges through a variety of studies. Dr. Irwin also stressed the vital role that NIA and other institutes at the National Institutes of Health (NIH) play in making this research possible.

 “As a junior investigator, this has been a very exciting time for me to start my career with a rapid advance in our understanding of the genetics and pathophysiology of AD and related conditions – these advances would not be possible without publicly-funded programs through the NIA, NINDS and other institutes at NIH,” said Dr. Irwin. “I am very enthusiastic and thankful to have the opportunity to help advocate for the mission of the NIA, as this directly leads to the improvement in the care of patients I treat with AD and related disorders.”

Full presentation slides:

Kathy Jedrziewski, PhD, Deputy Director of the Institute on Aging, is the current Chair of Friends of the NIA (FoNIA). For more information on FoNIA, click here

Full 2017 FoNIA Briefing Flyer

The 14th Annual Jane Wright Symposium on Parkinson’s Disease for Patients and Caregivers

Published by Benjamin Deck, Udall Coordinator 

The 14th annual Jane Wright conference was held on June 15th at the Sheraton Hotel on City Line Avenue in Philadelphia, PA. The Jane Wright conference is an annual symposium that brings together the local Parkinson’s community to hear presentations around a central theme and to make people with Parkinson’s (PwP) and their loved ones aware of available resources. The theme this year was, “Hot Topics in Parkinson’s Disease” and the attendance reached an all-time high of over 200 people.

Professor Emeritus of Neurology, Dr. Matthew Stern, MD opened the conference with his lecture on Parkinson’s history and discussed updates to James Parkinson’s original definition of Parkinson’s disease (PD). Some of the issues Dr. Stern outlined were disparate pathologies in PD, PD subtypes, and the idea that current diagnostic criteria do not allow for early diagnosis in PD. One precluding factor of early diagnosis is that motor symptoms are typically not present until later stages of the disease.

The second speaker was the newly appointed Director of Medicine at the Penn Neurological Institute, Dr. Andrew Siderowf, MD. Dr. Siderowf presented new therapeutics in PD such as Safinamide, Rytary, Droxidopa, and Primavanserin. Dr. Siderowf’s presentation also touched on newer surgical interventions for PD such as Focused Ultrasound and Duopa. The presentation then focused on disease modifying procedures and medications that are currently under development, i.e. gene therapy, alpha synuclein anti-body trials, and treatments specialized for specific genetic mutations in PD. View his presentation here.

Assistant Professor of Neurology, Dr. Lama Chahine, MD, spoke of biomarkers and the crucial role that they will play in the diagnosis, prognostication, and treatment of PD. Dr. Chahine made the compelling case for further research on biomarkers in PD by showing the subjectivity of in-clinic motor exams, which are currently the gold standard for a PD diagnosis in movement disorder clinics. Dr. Chahine emphasized that biomarker discovery in cerebral spinal fluid (CSF), blood, and tissue sampling (collected most recently for this trial), could one day diagnose patients earlier and/or better treat the disease.

The final speaker at this year’s Jane Wright Conference was Movement Disorders Fellow, Dr. Michelle Fullard, MD. Dr. Fullard’s presentation outlined the recent technological advances that are helping to deliver better and more accessible treatments. Telemedicine has been implemented in many clinics and decreases travel burden for PD patients who often find this to be a barrier to quality care. Telemedicine allows physicians to remotely diagnose and treat individuals through the use of telecommunications technology. Dr. Fullard also discussed wearable devices that can track a PD patient’s movements through the use of accelerometers and other such technology. The hope its that these devices would allow movement disorder specialists to better understand the motor complications of their patients.

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Lastly, Dr. Stern was awarded an Proclamation signed by Mayor Jim Kenney that decrees April as Parkinson’s Awareness Month in Philadelphia. The proclamation was presented by Ms. Lori Katz and a represenative from Mayor Kenney’s office (pictured above).

View all presentation slides here.

 

Genetics of Aging-Related Neurodegeneration: The Sylvan M. Cohen Annual Retreat & Poster Session 2017

077On Tuesday, May 23, 2017, the Institute on Aging (IOA) hosted their annual Sylvan M. Cohen Retreat and Poster Session in collaboration with co-sponsors, the Penn Neurodegeneration Genomics Center (PNGC).

The 2017 retreat focused on the ‘Genetics of Aging-related Neurodegeneration’ and for the second year in a row, it began with opening remarks from the Dean of the Perelman School of Medicine, J. Larry Jameson, MD, PhD. “I’m mainly here to thank you for your scientific collaboration,” said Dean Jameson. He used this time to express the importance and impact of these contributions in the field of genetics and aging, especially in trying to solve the puzzle of very complex conditions such as neurodegeneration.

Lectures were presented by Penn’s Gerard (Jerry) D. Schellenberg, PhD, Director of the PNGC, Adam Naj, PhD, Assistant professor of Epidemiology in Biostatistics and Epidemiology, and Nancy Zhang, PhD, Assistant professor of Statistics, as well as this year’s keynote speaker, Philip De Jager, MD, PhD, Associate Neurologist at Brigham and Women’s Hospital and Associate Professor of Neurology at Harvard Medical School.

Lectures:

  • “Alzheimer’s Disease Genetics; Progress in Gene Therapy” – Jerry Schellenberg, PhD
  • “Genetic Risk Factors Associated with Coincident Alzheimer’s and Parkinson Disease in Neuropathologically Confirmed Cases” – Adam Naj, PhD
  • “Structural Variant Profiling in Alzheimer’s Disease Genetics” – Nancy Zhang, PhD
  • “The molecular network map of the aging cortex: v1.0: an integrative approach targets the epigenomic and inflammatory components of Tau pathology” – Philip De Jager, MD, PhD

As usual, the event concluded with the annual poster session on aging. Prizes were awarded to the top posters in each of the following categories: Basic Science and Clinical Research/Education & Community.

Poster Winners:

BASIC SCIENCE:

1st Place:

172Title: “Integrative analysis identifies immune-related enhancers and IncRNAs perturbed by genetic variants associated with Alzheimer’s disease”
Presenter: Alexandre Amlie-Wolf
Authors: Alexandre Amlie-Wolf, Mitchell Tang, Jessica King, Beth Dombroski, Elizabeth Mlynarski,Yi-Fan Chou, Gerard D. Schellenberg, Li-San Wang
Affiliation(s): University of Pennsylvania, Genomics and Computational Biology Graduate Group

2nd Place:

173Title: “Differential Vulnerability to a-synuclein Pathology Among Neuronal Subpopulations”
Presenter: Luna Esteban
Authors: Luna Esteban, Dawn M. Riddle, Virginia M.Y. Lee, Kelvin C. Luk
Affiliation(s): Center for Neurodegenerative Disease Research

 


Clinical Research/Education & Community

1st Place:

175Title: “Correlates of Sleep Indices Among Community Dwelling Older Adults Enrolled in a Collaborative Care Management Program”
Presenter: Ashik Ansar
Authors: Ashik Ansar, MD, PhD, Shahrzad Mavandadi, PhD, Kristin Foust, Suzanne DiFilippo, RN, Joel E.. Streim, MD, David W. Oslin, MD
Affiliation(s): Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania

2nd Place:

176Title: “The Impact of Cognitive Reserve and Brain Atrophy on Survival in Neurodegenerative Diseases”
Presenter: Carrie Caswell
Authors: Carrie Caswell, MS (1), Sharon X. Xie, PhD (1), Murray Grossman, MD, EdD (1), Corey T. McMillan, PhD (1), Lauren M. Massimo, PhD, CRNP (1,2)
Affiliation(s): (1) University of Pennsylvania, (2) Penn State University

To view the full lectures from the 2017 Sylvan M. Cohen Annual Retreat, click here.

To view more photos from the 2017 Sylvan M. Cohen Annual Retreat, click here.

 

Penn’s CNDR celebrates 25 years of groundbreaking research with the supporters and friends who make it all possible

screen-shot-2016-11-08-at-3-01-13-pmThis year, the Center for Neurodegenerative Disease Research is celebrating its 25th anniversary in a big way. Penn Medicine organized an intimate anniversary event generously hosted by longtime supporters and friends of CNDR, Bob Lane, an Institute on Aging External Advisory Board (IOA EAB) member, and his wife Randi Zemsky, at their home in the Rittenhouse Square section of Philadelphia. 

 

The event celebrated the groundbreaking work of CNDR over the past 25 years and highlighted research breakthroughs still on the horizon. It was also an opportunity to bring together and thank many of the center’s supporters. The event was attended by David B. Roth, MD, PhD, Chair of the Department of Pathology and Laboratory Medicine, CNDR researchers, IOA EAB members, supporters of the Center and close friends of the hosts.

Stay tuned for our special edition CNDR 25th Anniversary Newsletter coming early next year.

“To sleep, per chance to age… and avoid Alzheimer’s disease”: A recap of the 2016 Sylvan M. Cohen Annual Retreat

On Wednesday, June 8, 2016, the Institute on Aging hosted its annual Sylvan M. Cohen Retreat and Poster Session. This year’s retreat, titled “To sleep, per chance to age… and avoid Alzheimer’s disease,” was co-sponsored by Penn’s Center for Sleep and Circadian Neurobiology and explored the effects of sleep loss and it’s possible link to Alzheimer’s and other neurodegenerative conditions.

corrected_DJquoteAs usual, the event began with lunch and a series of lectures, but this year we had the pleasure of having J. Larry Jameson, MD, PhD, dean of the Perelman School of Medicine (PSOM), join us for opening remarks.

He expressed his excitement to see such collaboration amongst the two sponsoring centers and encouraged more of this, not only in the PSOM, but also across the University as a whole. “One of the secrets at Penn Medicine is that we have these catalytic centers and institutes and it’s even more impressive that there is often cross fertilization between them,” explained Dean Jameson.

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Keynote speaker, David M. Holtzman, MD, professor and chairman, Department of Neurology at Washington University School of Medicine, kicked off the lectures by discussing his research in “Understanding the Relationships between Sleep, Protein Aggregation, and Alzheimer’s disease.”

Other topics, covered by our Penn Presenters, included (click for video interviews):

Immediately following the lectures, researchers from the University of Pennsylvania and beyond presented their current aging-related work at our annual Poster Session. Categories included basic science, clinical research, & education and community and awards were given to the top posters.

Poster Winners

BASIC SCIENCE

1st Place
BasicSciecne1Enhancing a WNT-telomere feedback loop restores intestinal stem cell function in a human organotypic model of dyskeratosis congenita
Presenter: Dong-Hun Woo
Authors: Dong-Hun Woo, Qijun Chen, Ting-Lin B. Yang, M. Rebecca Glineburg, Carla Hoge, Nicolae A. Leu, F. Brad Johnson, and Christopher J. Lengner

 

2nd Place
BasicSciecne2AB Plaques Mediate Neuritic Plaque-like Tau Pathology that is Distinct from Perikaryal Tau Inclusions
Presenters: Zhuohao He
Authors: Zhuohao He, Jing L. Guo, Jennifer D. McBride, Lakshmi Changolkar, Bin Zhang, Ronald J. Gathagan, Hyesung Kim, Sneha Narasimhan, Kurt R. Brunden, John Q. Trojanowski, Virginia M.-Y. Lee


CLINICAL RESEARCH and EDUCATION & COMMUNITY *

1st Place
ClinRes1Tau Pathology Influences Dementia Onset and Survival in Lewy Body Spectrum Disorders
Presenter: David Irwin
Authors: David J. Irwin, MD MSTR, Murray Grossman MD, Daniel Weintraub MD, Howard I. Hurtig MD, John E. Duda MD, Sharon X. Xie PhD, Edward B. Lee MD PhD, Vivianna M. Van Deerlin MD, PhD,Oscar L. Lopez MD, Julia K. Kofler MD, Peter T. Nelson, MD PhD, Randy Woltjer MD PhD, Joseph F. Quinn MD, Jeffery Kaye MD, James B Leverenz MD, Debby Tsuang MD, MSc, Katelan Longfellow MD, Dora Yearout BS, Walter Kukull PhD, C. Dirk Keene MD, PhD, Thomas J. Montine MD, PhD, Cyrus P. Zabetian MD MS, John Q. Trojanowski MD PhD

2nd Place
ClinRes2Clinical Profile of Older Adults with Mild or No Cognitive Impairment Who Receive Prescriptions for Cholinesterase Inhibitors and/or Memantine: A descriptive study from the PACE/PACENET BHL Caregiver Resources, Education and Support (CREST) Program
Presenter: Romika Dhar, MD
Authors: Romika Dhar, MD; Amy Benson, MSEd; Joel E. Streim, MD; David W. Oslin, MD

* Due to the number of posters submitted, the categories for Clinical Research and Education & Community were combined.

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To view some of the full lectures from our retreat, click here.
* Please note: Some of the lectures are not available to view due to unpublished data being presented *

View more photos from our 2016 Sylvan M. Cohen Retreat Facebook album here.